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Finding a hotspot
In June 2011, Dr Littman and her research team reported that they'd found what they called a statistical hotspot in dogs affected with PLN compared with geriatric wheatens who were not affected with the disease. Simply, two genes in the hotspot area each have a DNA change that causes 'an alteration in the proteins they encode' (SCWTCA Health News 12/2011). The theory is that the DNA changes are what causes the leakage of protein. A much more detailed explanation can be read on the SCWTCA Health Page in the latest issue of the club's health news.
PLN DNA Testing
Also in the SCWTCA Health News (latest issue), is that preparations are being made to accept DNA samples to test for PLN. The good news for Australian wheaten owners is that cheek swabs will be accepted rather than bloods. See the link above for more details.
Open Register
A number of countries have what's known as an 'open register' of dogs with PLE/PLN and other diseases. The most well known one is in the United States and contains a list of dogs affected by PLE and PLN, as well as other diseases such as IBD and RD. The Open Register lists the name of the affected dog, as well as its sire and dam. Membership of the Open Register enables you to receive a copy of the register when it is updated by Dr Littman. Information on the Open Register can be found at the US wheaten club website.
The US Open Register has now been updated (2009). If you wish to see how your dog is related to other dogs that have died of PLE or PLN (or both), it is recommended that you become a member of the Open Register.